2 Advantages of Angelica Gigas & Side Effects

2 Advantages of Angelica Gigas & Side Effects

Nicknamed the”female ginseng”, Angelica Gigas has a very long background in traditional Korean medicine. Largely used for gynecological health, Angelica Gigas has the capability to combat inflammation and protect the brain.

What’s Angelica Gigas?

Angelica Gigas (full title: Angelica Gigas Nakai) can also be referred to as Korean Angelica, giant Angelica, and cham-dang-gui. It is largely found in Korea, together with two other closely-related Angelica species found in Japan and China.

ANGELICA gigas - Woottens Plant Nursery Suffolk

The Chinese species is Angelica Sinensis, also known as dong Quai or Danggui. There are differences in the chemical makeup and potential medical uses between Angelica Gigas and Angelica Sinensis. Angelica Sinensis is generally utilized to promote blood flow, while Angelica Gigas is favored for menstrual problems and general gynecological health.

Traditionally, the dried root of Angelica Gigas is boiled in water before being taken orally.


The major chemical components of Angelica Gigas are decursin and decursinol angelate. Both of these molecules are rapidly converted to decursinol in the liver. This implies that decursinol might be the actual active element resulting in the observed effects.

Other compounds in Angelica Gigas contain:

  • Nodakenin
  • Angelan
  • Caffeic acid

Mechanisms of Action

Both decursin and nodakenin decrease acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine.

Angelan raises the production of the cytokines IL-2, IL-4, IL-6, and IFN-γ, triggers B cells to produce more antibodies, and promotes the maturation of immune cells (dendritic cells) by activating TLR4 signaling pathways.

Caffeic acid activates the estrogen receptor hER-β.


  • May improve menopausal symptoms
  • May improve and preserve brain function
  • Few negative effects reported
  • Only 2 clinical trials carried out thus far
  • Most of the Possible health benefits have only been investigated in cells and animals
  • May interact with blood thinners

Health Benefits of Angelica

Insufficient Evidence for:
1) Menopausal Symptoms

Angelica Gigas are traditionally used to treat irregular menstrual growth and menopausal symptoms because of the estrogenic action. Studies in cells indicate its consequences might be similar to those of hormone replacement therapy.

EstroG-100 is a natural formulation that contains Angelica Gigas and also other herbs (Cynanchumwilfordii and Phlomis umbrosa). At a clinical trial on 64 pre-, peri-, and post-menopausal ladies, EstroG-100 improved menopausal symptoms (vasomotor, paresthesia, insomnia, anxiety, melancholia, vertigo, fatigue, and rheumatic pain) without serious unwanted effects.

Angelica Gigas normalized estrogen and progesterone amounts and decreased bone loss in menopausal rats.

An herbal formulation with Angelica Gigas, Cassia cinnamon, and Cnidium Officinale reduced bone loss, weight reduction, and uterine thinning in menopausal rats by activating estrogen-responsive genes.

Although the results are promising, a single clinical trial (using Angelica Gigas in conjunction with other herbs) and some creature and cell-based research cannot be considered adequate evidence to support using Angelica Gigas to improve menopausal symptoms. More clinical trials larger populations are required to confirm these preliminary findings.

2) Brain Function

Research measuring brain electric activity in 20 healthy volunteers found that smelling Angelica Gigas crucial oil increased the level of brain waves associated with language learning capability.

Brain cell damage can occur due to many factors, including inflammation and oxidative stress. Oxidative stress can lead to damage to DNA, proteins, and fats.

Angelica Gigas averted the death of brain cells in cell-based studies, suggesting its potential to prevent bronchial disorders.

A standardized alcohol extraction in Angelica Gigas named INM-176 diminished cognitive deficits and diminished memory loss in mice treated with scopolamine.

ESP-102 is a formulation with Angelica Gigas root, Saururus Chinensis fruit, also Schisandra Chinensis fruit in an 8:1:1 ratio. ESP-102 shielded rat brain cells from glutamate toxicity and aided the animals to recover from memory impairment.

The formulations LMK02 (Angelica Gigas and 7 additional herbs/mushrooms) and LMK03 (Angelica Gigas and Poria cocos mushroom) protected rat hippocampal brain cells from cell damage and inhibited neurotoxicity and oxidative stress in human neuroblastoma cells. LMK02 and LMK03 also reduce Alzheimer’s-like symptoms in mice.

Bozhougyiqi-tang (BZYQT) is a herbal medicine created from Angelica Gigas, ginseng, Astragalus, and other herbs. It secures mouse hippocampal cells in cell damage and led to greater cognitive functionality.

Angelica Gigas additionally prevented brain damage and helped offset the start of symptoms of pre-Alzheimer’s disorder in mice.

Treatment of mice with decursin reduced memory loss and protected brain cells from oxidative stress. Similarly, decursinol diminished memory loss in mice and protected brain cells from glutamate toxicity.

The research animals are promising, but just a small human study was completed. Larger, more robust clinical trials are required to ascertain if Angelica Gigas help improves and preserve brain functioning.

Animal and Cell Research (Lack of Proof )

No clinical evidence supports the use of Angelica Gigas for some of the states listed within this section. Below is a summary of the present creature and cell-based research, which should guide further investigational efforts. However, the research should not be interpreted as supportive of any health benefit.


Angelica Gigas reduced inflammation due to too much nitric oxide and inflammatory molecules such as TNF-alpha and IL-6 in mice and rats.

In mice with psoriasis, its compounds nodakenin and decursin reduced itching, and the severity of the lesions, and blood antibody levels.

The herbal formula APR (Angelica Gigas, Panax ginseng, and Rhus verniciflua) is used to curb inflammation. In inflamed mouse macrophages (immune cells that engulf foreign particles), APR decreased oxidative stress and enhanced mitochondrial function.

The two decursin and decursinol angelate shielded rat adrenal gland cells in toxins and decreased inflammation.

Preventing Weight Gain

Decursin prevented insulin from inducing fat cells to grow, radically reducing fat accumulation and weight gain, in mice. Mice treated with decursin had decreased levels of leptin, resistin, IL-6, and MCP-1 (that have been raised by a high-fat diet).

Bone Loss

In rats, Angelica Gigas averted a reduction in bone mineral density, a sign of bone loss that may result in osteoporosis. Additionally, Angelica Gigas increased bone stiffness and strength compared to controls and prevented bone loss in rats that were treated’ tibias.

Nicotine Addiction

Smelling Angelica Gigas essential oils reduced sensitivity to nicotine from nicotine-addicted mice by blocking the release of dopamine in response to this drug.


Decursinol blocked pain perception in mice.

Reducing Skin Aging

Collagen is an abundant protein within the skin, whose amounts diminishes with age.

Angelica Gigas increased collagen synthesis in human connective tissue cells.


Below, we will explore some preliminary studies on Angelica Gigas’ potential anticancer effects. It is still in the animal and cell stage and additional clinical trials have yet to determine if its extract may be helpful in cancer therapies.

Do not under any circumstances attempt to replace traditional cancer treatments with Angelica Gigas or some other supplements. If you would like to use it as a reassuring measure, speak with your doctor to avoid any unexpected interactions.

Angelica Gigas’ chemicals decursin, decursinol angelate, and decursinol decreased the growth and spreading of the following cancer types in mice and improved their lifespan:

  • Lung
  • Prostate
  • Colon
  • healthy tissue and bones (sarcoma)

In cell-based research, these three compounds were effective against those and other cancer types for example:

  • Breast
  • Bladder
  • Blood (myeloma, leukemia, lymphoma)
  • Ovarian
  • Cervical

Decursin and decursinol angelate additionally lessen the number of androgen receptors. These receptors are vital to the growth of prostate cancer, which implies their possible effectiveness for this type of cancer.

Side Effects and Contraindications

Remember that the safety profile of Angelica Gigas is comparatively unknown, given the lack of well-designed clinical studies. The list of side effects and drug interactions under is not a certain one and you should speak to your physician about other possible side effects according to your health condition and possible drug or nutritional supplements.

Based on the absence of adverse effects observed in clinical trials and its conventional use in Korean medicine, Angelica Gigas is possibly safe when taken at normal doses.

Due to the absence of security data, pregnant and pregnant women should avoid Angelica Gigas.

Alcohol extracts of aerial parts (flower, leaf, and stem) of Angelica Gigas aroused the activity of alcohol dehydrogenase and aldehyde dehydrogenase, enzymes involved in alcohol and drug processing, in test tubes. This may increase the pace at which the body processes alcohol and other medications.

Angelica may lower the blood’s ability to clot. Therefore, it should not be utilized along with blood-thinning drugs such as warfarin and Xarelto without consulting a doctor.


Since Angelica Gigas are not accepted by the FDA for any illness, there isn’t any official dose. Users and supplement manufacturers have established unofficial dosages based on trial and error. Discuss with your doctor if Angelica Gigas may be useful as a complementary strategy in your case and dose you should take.

In treating menopausal symptoms, participants took 2 capsules each day, with each capsule containing 257.05 mg EstroG-100 powder.

For aromatherapy, research participants smelled a small volume (10 uL put onto filter paper) of pure Angelica Gigas extract for 1 to 2 minutes.

User Reviews

The opinions expressed in this section are only those of Angelica Gigas users, who may or may not have scientific or medical training. Their reviews don’t represent the opinions of SelfHacked. SelfHacked does not endorse any particular item, service, or treatment.

Do not consider user adventures as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare providers due to something you have read on SelfHacked. We know that reading individual, real-life encounters can be a very helpful resource, but it’s not a replacement for professional medical advice, diagnosis, or therapy from a qualified healthcare provider.

Nearly all users gave positive reviews of an anti-inflammation formula (specifically for joint pain relief) containing Angelica Gigas extract (Decursinol-50), stating that it immediately relieved pain without side effects.

Some users carrying yet another Angelica Gigas infusion (INM-176) reported that it improved their memory.

Most testimonials of EstroG-100 (utilized in the treatment of menopause symptoms) reported good results at relieving hot flashes, mood swings, and night sweats. However, some stated that they experienced no result. The only reported side effect by one user has been difficulty falling asleep after taking EstroG-100 at night.

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